ea0090rc6.2 | Rapid Communications 6: Endocrine-related Cancer | ECE2023
Garcia Vioque Victor
, Trinidad Moreno Montilla Maria
, Blazquez Encinas Rey Ricardo
, Mangili Federica
, Martinez Montes Angel Mario
, Alors-Perez Emilia
, Culler Michael D
, Pedraza-Arevalo Sergio
, Robledo Mercedes
, P. Castano Justo
, Ibanez Costa Alejandro
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine neoplasms (NENs) that arise in the adrenal medulla and paraganglia, respectively. As occurs in the rest of NENs, PPGLs commonly present a high density of somatostatin receptors (SSTs) on their membrane. However, unlike in most NENs, somatostatin analogues (SSAs) do not represent a suitable therapeutic target in PPGLs, and the mechanisms underlying this mismatch are still unclear. In this study, we aim to iden...